Physical mechanisms explaining DNA and RNA twist changes
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The double-helix structure of DNA is deformed by environmental stimuli, which will then affect gene expression, and eventually trigger a sequence of cellular processes. Recent research led by a physicist from City University of Hong Kong (CityU) observed substantial DNA deformations by ions and temperature changes. The researchers developed one simple physical model to explain DNA deformations. These results provide new insights into the molecular mechanisms of cellular responses to ions and temperature changes and can be used to control gene expression using ions and temperature.
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Nucleic Acid Secondary Structure - an overview
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Nucleosome Dynamics Derived at the Single-Molecule Level
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Frontiers DNA structural properties of DNA binding sites for 21 transcription factors in the mycobacterial genome
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Pharmaceutics, Free Full-Text
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Structure and proposed DNA delivery mechanism of a marine roseophage
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PPT - Mechanisms of Transcriptional Repression PowerPoint
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CRISPR–Cas9 bends and twists DNA to read its sequence
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Publications, Department of Physics
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Epigenetic regulation in major depression and other stress-related
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Soft Matter and Biophysics, Department of Physics
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Mechanism of reaction of RNA-dependent RNA polymerase from SARS
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