Genes, Free Full-Text

Breast cancer is the most common women’s malignancy in the world and, for subgroups of patients, treatment outcomes remain poor. Thus, more effective therapeutic strategies are urgently needed. MicroRNAs (miRNAs) have emerged as promising therapeutic tools and targets, as they play significant roles in regulating key cellular processes by suppressing gene expression. However, additive opportunities involving miRNAs have been underexplored. For example, both miR-34a and miR-200c individually suppress the development of different types of cancer, but the cellular effects of their combined actions remain unknown. Here, we show that miR-34a and miR-200c levels are reduced in breast tumors compared to adjacent normal tissues and that this additively predicts poor patient survival. In addition, in cell lines, miR-34a and miR-200c additively induce apoptosis and cell cycle arrest, while also inhibiting proliferation, invasion, migration, stemness and epithelial-to-mesenchymal transition (EMT). Mechanistically, both miRNA-34a and miR-200c directly target HIF1-α and subsequently downregulate VEGFR, MMP9 and CXCR4, although combined miRNA-34a and miR-200c delivery suppresses mouse xenograft tumor development as effectively as individual delivery. We establish a model, supported by in vitro and clinical data, which collectively suggest that the co-delivery of miR-34a and miR-200c represents a promising novel therapeutic strategy for breast cancer patients.

Streamlining and Muller's ratchet hypotheses are commonly used to

Genes and Genetics (for Teens)

bäumlein 108 led

Biology, Free Full-Text, shotgun king igg

Stress and circulating cell-free mitochondrial DNA: A systematic review of human studies, physiological considerations, and technical recommendations - ScienceDirect

Free DNA Upload Sites To Learn More About Your Health - SelfDecode Health [SEPTEMBER 2022]

Environmental response in gene expression and DNA methylation reveals factors influencing the adaptive potential of Arabidopsis lyrata

Cells Free Full Text Hepatitis B Virus Entry Into Cells 19030

Genes, Free Full-Text, overloaded tradução

The cell-free DNA methylome captures distinctions between localized and metastatic prostate tumors

Genes Free Full Text Sex Determination Using Rna Sequencing

Homeotic Genes and Body Patterns

Genes Free Full Text Size And Content Of The Sex Determining

Genes, Free Full-Text, overloaded tradução