IJERPH, Free Full-Text
![](https://pub.mdpi-res.com/ijerph/ijerph-19-09362/article_deploy/html/images/ijerph-19-09362-g001.png?1659182605)
Aluminum is an element found in nature and in cosmetic products. It can interfere with the metabolism of other cations, thus inducing gastrointestinal disorder. In cosmetics, aluminum is used in antiperspirants, lipsticks, and toothpastes. The aim of this work is to investigate aluminum bioavailability after accidental oral ingestion derived from the use of a toothpaste containing a greater amount of aluminum hydroxide than advised by the Scientific Committee on Consumer Safety (SCCS). To simulate in vitro toothpaste accidental ingestion, the INFOGEST model was employed, and the amount of aluminum was measured through the ICP-AES analysis. Tissue barrier integrity was analyzed by measuring transepithelial electric resistance, and the tissue architecture was checked through light microscopy. The margin of safety was also calculated. Overall, our results indicate that the acute exposure to aluminum accidentally ingested from toothpastes is safe for the final user, even in amounts higher than SCCS indications.
![](https://www.mdpi.com/ijerph/ijerph-19-09586/article_deploy/html/images/ijerph-19-09586-g006-550.jpg)
IJERPH Free Full-Text Bayesian Modeling Of COVID-19 To, 42% OFF
![](https://pub.mdpi-res.com/ijerph/ijerph-19-06541/article_deploy/html/images/ijerph-19-06541-g001-550.jpg?1653648347)
Images
![](https://pub.mdpi-res.com/img/journals/ijerph-logo-social.png?f4a7c3c190986910)
Sunrise Sign Language Academy Sign language Courses, Translation
![](https://www.mdpi.com/ijerph/ijerph-19-12353/article_deploy/html/images/ijerph-19-12353-g001.png)
IJERPH, Free Full-Text, analysis chess lichess
![](https://www.mdpi.com/ijerph/ijerph-20-03899/article_deploy/html/images/ijerph-20-03899-g001-550.jpg)
IJERPH, Free Full-Text
![](https://pub.mdpi-res.com/ijerph/ijerph-20-04940/article_deploy/html/images/ijerph-20-04940-g001.png?1678699196)
Social isolation linked to early death risk, study finds
![](https://pub.mdpi-res.com/ijerph/ijerph-20-04741/article_deploy/html/images/ijerph-20-04741-g001-550.jpg?1678678600)
IJERPH, Free Full-Text
Guruprasad Kamat on LinkedIn: IJERPH, Free Full-Text
![](https://pub.mdpi-res.com/ijerph/ijerph-19-01592/article_deploy/html/images/ijerph-19-01592-g001.png?1643531297)
IJERPH, Free Full-Text
![](https://pub.mdpi-res.com/ijerph/ijerph-13-00531/article_deploy/html/images/ijerph-13-00531-g001-1024.png?1467101204)
IJERPH, Free Full-Text
![](https://www.researchgate.net/publication/355478257/figure/fig2/AS:1127567402766346@1645844426372/Variation-of-daily-TMIN-TMAX-and-new-cases-of-COVID-19-in-the-humid-to-sub-humid_Q320.jpg)
IJERPH Free Full-Text Bayesian Modeling Of COVID-19 To, 42% OFF
![](https://i.pinimg.com/736x/7c/57/76/7c5776e3111dafe347e831f42c6c03b7.jpg)
IJERPH, Free Full-Text
![](https://pub.mdpi-res.com/ijerph/ijerph-11-00067/article_deploy/html/images/ijerph-11-00067-g001-1024.png?1403141613)
IJERPH, Free Full-Text
![](https://www.mdpi.com/ijerph/ijerph-20-04217/article_deploy/html/images/ijerph-20-04217-g001-550.jpg)
IJERPH, Free Full-Text