Surgical stress and cancer progression: the twisted tango
Surgical resection is an important avenue for cancer treatment, which, in most cases, can effectively alleviate the patient symptoms. However, accumulating evidence has documented that surgical resection potentially enhances metastatic seeding of tumor cells. In this review, we revisit the literature on surgical stress, and outline the mechanisms by which surgical stress, including ischemia/reperfusion injury, activation of sympathetic nervous system, inflammation, systemically hypercoagulable state, immune suppression and effects of anesthetic agents, promotes tumor metastasis. We also propose preventive strategies or resolution of tumor metastasis caused by surgical stress.
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Cancer Stem Cells are Actually Stem Cells with Disordered
Cancers, Free Full-Text
PDF) Surgical stress and cancer progression: the twisted tango
IJMS, Free Full-Text
New insights into the correlations between circulating tumor cells
New insights into the correlations between circulating tumor cells
Multifunctional nanoparticles precisely reprogram the tumor
PDF) Perioperative Inflammatory Response and Cancer Recurrence in
Microenvironmental regulation of therapeutic response in cancer
Pharmaceuticals, Free Full-Text
Thorny ground, rocky soil: Tissue-specific mechanisms of tumor
Perioperative factors associated with survival following surgery