Full agonists, partial agonists and inverse agonists

An agonist is a ligand that binds to a receptor and alters the receptor state resulting in a biological response. A full agonist reaches the maximal response capability of the system, and a partial agonist does not (even at full receptor occupancy). A partial agonist acts as an antagonist in the presence of a full agonist (if they compete for the same receptors). An inverse agonist is a ligand that by binding to receptors reduces the fraction of them in an active conformation. Spare receptors are said to exist wherever a full agonist can cause a maximum response when occupying only a fraction of the total receptor population.

Solved 1. True or False: You have two inverse agonists with

Emerging concepts of G protein-coupled receptor (GPCR) function and drug discovery - Drug Discovery World (DDW)

VM 531 Day 4 Flashcards

Receptor antagonist - Wikipedia

inverse agonist

How to understand from the L*R graph, do we deal with agonist, antagonist and inverse agonist - Quora

What is a drug? and how does a drug work? Different types of agonist and antagonist

2.Mechanism of drug actons

i.ytimg.com/vi/PVGbbgkfEvc/mqdefault.jpg

Ghrelin Receptor: High Constitutive Activity and Methods for Developing Inverse Agonists - ScienceDirect