Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling

Frontiers T Cell Fitness and Autologous CAR T Cell Therapy in Haematologic Malignancy

Stem-like memory T cells are generated during hollow fiber perfusion-based expansion and enriched after cryopreservation in an automated modular cell therapy manufacturing process - Cytotherapy

Mechanisms of CAR T cell exhaustion and current counteraction strategies. - Abstract - Europe PMC

AACR Tumor Immunology and Immunotherapy Meeting 2023

Sung Chang Lee, PhD,Ms (@SungChangLee3) / X

TCF1/TCF7 (C63D9) Rabbit mAb (Alexa Fluor ® 647 Conjugate) 6709S from Cell Signaling Technology

Steering CAR T cell epigenetic programs by tweaking manufacturing protocol - ScienceDirect

B cell targeting in CAR T cell therapy: Side effect or driver of CAR T cell function?

Transient “rest” induces functional reinvigoration and epigenetic remodeling in exhausted CAR-T cells

Evan Weber - Assistant Professor - University of Pennsylvania Perelman School of Medicine