Identification and Strategies to Mitigate High Total Clearance of
![](https://pubs.acs.org/cms/10.1021/acs.molpharmaceut.2c00014/asset/images/medium/mp2c00014_0011.gif)
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Christina CHAN, Researcher, PhD, AstraZeneca, London
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Identification and Strategies to Mitigate High Total Clearance of
![](https://pubs.acs.org/cms/10.1021/acs.molpharmaceut.2c00014/asset/images/large/mp2c00014_0003.jpeg)
Identification and Strategies to Mitigate High Total Clearance of
![](https://pubs.acs.org/cms/10.1021/acs.molpharmaceut.2c00014/asset/images/medium/mp2c00014_0004.gif)
Identification and Strategies to Mitigate High Total Clearance of
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Identification and Strategies to Mitigate High Total Clearance of
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William MCCOULL, AstraZeneca, London, AZ
![](https://www.researchgate.net/publication/320026079/figure/fig1/AS:741128152297474@1553710129903/On-the-left-a-schematic-of-the-glucose-metabolic-pathway-showing-the-PFKFB3-position_Q320.jpg)
Jon WINTER-HOLT, Senior medicinal chemist
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Physicochemical Determinants of Human Renal Clearance
![](https://www.researchgate.net/publication/347488259/figure/fig1/AS:984863658242054@1611821202761/Comparison-of-unliganded-MerTK-with-type-1-complexes-A-Superposition-of-apo-MerTK_Q320.jpg)
Comparison of unliganded MerTK with type 1 complexes. (A
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Identification and Strategies to Mitigate High Total Clearance of
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PDF) Predicting when Biliary Excretion of Parent Drug is a Major